A type 2 diabetes natural diet treatment against insulin resistance with DIABATROL™

A type 2 diabetes natural diet treatment against insulin resistance with DIABATROL™

 
 

 

The Science behind Diabatrol™

Choose A New and Natural Remedy for Your Diabetic Diet

Summary:
  • For most concerned with Type 2 diabetes and pre-diabetes, glucose AND lipid management are important.
  • Insulin resistance plays a major role in Type 2 diabetes and increases the risk of diabetic complications such as heart disease, eye, nerve, and kidney damage
  • Oxidative stress is a factor in insulin resistance.
  • Within the diabetic condition, oxidative stress is increased and antioxidant defenses are diminished.
  • Some antioxidants, minerals and vitamins have been clinically shown to reduce oxidative stress and insulin resistance in Type 2 diabetes.
  • Diabatrol™ is a nutraceutical dietary supplement that has been clinically documented to lower and stabilize blood sugar levels, reduce insulin resistance and have beneficial effects on lipid management.

Diabetes is a multifaceted health condition, which affects a number of metabolic functions in the body. Frequently the diabetic condition involves alterations to both glucose and lipid (fatty acids and/or cholesterol) metabolism. Diet plays a very important role in managing both these metabolic issues. Positive changes in the diet can help create a healthy nutritional foundation and complement an overall diabetes management program.  

Medical researchers are in general agreement that the symptoms of Type 2 diabetes and pre-diabetes most often result from insulin resistance and/or reduced insulin secretion. Insulin resistance is the primary cause of elevated blood glucose levels in patients with Type 2 and pre-diabetic conditions.[1, 2] Insulin resistance is also an indicator of unhealthy levels of triglycerides and HDL (good cholesterol), and increased risk of heart disease.[3-5] With regular daily use, Diabatrol’s active ingredients help reduce oxidative stress and insulin resistance, thereby promoting healthy glucose metabolism and reducing glucose levels in the bloodstream.

Total Antioxidant Capacity of Various Fruits and Vegetables Total Antioxidant Capacity of Diabatrol compared to various fruits and vegetables
1. Calculations for equivalent daily servings of Diabatrol active ingredients based on United States Dept. of Agriculture (USDA) study reported in Journal Agricultural and Food Chemistry, 2004.

Much medical research has focused on the role of oxidative stress in diabetes and its related health complications.[6] Numerous studies have linked increased oxidative stress to insulin resistance.[7-12] When patients have high blood sugar levels, oxidative stress is increased [11, 12, 13] and antioxidant defenses are diminished.[13-15] In both healthy individuals and diabetic patients, reduction of oxidative stress was found to improve insulin sensitivity as well as improve Beta-cell function.[14]

Oxidative stress can greatly increase other health risks associated with diabetes, such as, heart disease, kidney dysfunction, and damage to the eyes and nerve system. Clinical trials in patients treated with antioxidants have demonstrated improved insulin sensitivity in cases of insulin resistance.[16–19] Diabatrol is high in natural antioxidants [20] and can be integral in maintaining healthy glucose metabolism.

Insulin resistance in patients with Type 2 diabetes and pre-diabetes is frequently associated with high triglyceride and low HDL (good cholesterol) levels.[21-25] Heart disease is the most common complication for patients with diabetes or pre-diabetes symptoms. Lowering unhealthy LDL cholesterol and triglyceride levels, and improving HDL levels, are important aspects of minimizing heart disease risks. Insulin resistance elevates insulin levels within the body. High insulin levels influence lipid metabolism and increase circulating levels of triglycerides and LDL. The active ingredients in Diabatrol have been clinically documented to significantly lower LDL cholesterol and triglycerides in humans and animals.[20, 26, 27] Diabatrol also contains high levels of unique antioxidants not found in other whole grain products. These unique tocotrienols appear to lower LDL cholesterol levels and improve HDL levels.[20, 28]

Dieticians and Certified Diabetes Educators often recommend diets that provide a diverse balance of antioxidants, fiber, and important vitamins/minerals as nutritional supplements to help provide proper nutritional balance for healthy blood sugar metabolism. The synergistic nutrient interaction in such diets provides many health and wellness benefits that have been scientifically documented.[16-19] Diabatrol is a nutrient dense and balanced dietary supplement,  that has been formulated with this synergism in mind. The active ingredients in Diabatrol contain over eighty natural antioxidants, formulated with whole grain fiber, vitamins and minerals to provide a synergistic nutritional benefit for individuals concerned about oxidative stress, insulin resistance, and the health risks associated with diabetes.[20] The active ingredients in Diabatrol contain at least three novel antioxidants that are proven to be 10 to 33 times more effective at neutralizing oxidative stress than conventional antioxidants.[29, 30]

Vitamins and minerals alone per se do not reduce blood sugar levels. If they did, anyone using a complete multi-vitamin would not be concerned with diabetes. A healthy human body has resilient storage mechanisms for many vitamins and minerals. However, people with diabetes often retain lower levels of some key nutrients and antioxidants when compared to healthy subjects.[31-34] As an example, researchers found a 75% reduction in vitamin B1 among patients with Type 2 diabetes compared to subjects having normal glucose metabolism.[35] A common symptom of diabetes is frequent urination, up to five times the urination rate of non-diabetics. Nutrients are lost in these additional excretions.[36] In clinical trials, magnesium and chromium have been found to enhance insulin signaling and decrease insulin resistance.[37-44] Other minerals and vitamins also allow antioxidants to be more effective in reducing oxidative stress.[45, 46] Diabatrol contains high levels of all the mentioned vitamins and minerals plus additional nutrients needed in a healthy diabetic diet. See the Nutrition Facts page for a complete nutritional profile. 

Diabatrol is a trademark of Diabco Life Sciences, LLC.

References:
1. Tripathy D, et al. Insulin secretion and insulin sensitivity in relation to glucose tolerance. Diabetes. 2000. 49:975-980.
2. Abdul-Ghani MA, et al. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance. Diabetes. 2006. 55:1430-1435.
3. Watson KE, et al. Atherosclerosis in type 2 diabetes mellitus: the role of insulin resistance. Journal of Cardiovascular Pharmacology and Therapy. 2003 8:253-260.
4. Karhapaa P, et al. Isolated low HDL cholesterol: an insulin-resistant state. Diabetes. 1994. 43:411– 417.
5. Laakso M, et al. Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arteriosclerosis. 1990. 10:223–231.
6. Rosen P, et al. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metabolism Research & Review. 2001. 17:189-212.
7. Ceriello A. Oxidative stress and glycemic regulation. Metabolism. 2000. 49:27-29.
8. Maddux BA, et al. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of α-lipoic acid. Diabetes. 2001. 50:404.
9. Shimosawa T, et al. Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress. Hypertension. 2003. 41:1080-1085.
10. Urakawa H, et al. Oxidative stress is associated with adiposity and insulin resistance in men. Journal of Clinical Endocrinology Metabolism. 2003. 88:4673-4676.
11. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991. 40:405-412.
12. Paolisso G, et al. Evidence for a relationship between oxidative stress and insulin action in non-insulin-dependent (type II) diabetes patients. Metabolism. 1994. 43:1426-1429.
13. Jones AF, et al. Serum antioxidant activity in diabetes mellitus. Diabetes Research. 1988. 7:89-92.
14. Paolisso G, et al. Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics. American Journal of Physiology, Endocrinology and Metabolism. 1992. 263: E435-E440.
15. West IC. Radicals and oxidative stress in diabetes. Diabetic Medicine. 2000. 17:171–180.
16. Caballero B. Vitamin E improves the action of insulin. Nutrition Review. 1993. 51:339-348.
17. Evans JL, et al. Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction? Diabetes. 2003. 52:1-8.
18. Hirai N, et al. Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. American Journal of Physiology: Heart, Circulation & Physiology. 2000. 279:H1172-H1178.
19. Hirashima O, et al. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary angina: possible role of reactive oxygen species. Journal of the American College of Cardiology. 2000. 35:1860-1866.
20. Qureshi AA, et al. Effects of Stabilized Rice Bran, its Soluble and Fiber Fractions on Blood Glucose Levels and Serum Lipid Parameters in Humans with Diabetes Mellitus Types I and 2. Journal of Nutritional Biochemistry. 2002. 13:175-187.
21. Simonen PP, et al. Diabetes Contributes to Cholesterol Metabolism Regardless of Obesity. Diabetes Care. 2002. 1511-1515.
22. Bloomgarden ZT. American Association of Clinical Endocrinologists (AACE) Consensus Conference on the Insulin Resistance Syndrome. Diabetes Care. 2003. 26:1297-1303.
23. Reaven GM. Role of Insulin Resistance in Human Disease. Diabetes. 1988. 37:1595–607.
24. Saltiel AR. The Molecular and Physiological Basis of Insulin Resistance: Emerging Implications for Metabolic and Cardiovascular Diseases. Journal of Clinical Investigation. 2000. 106:163-164.
25. Pihlajamäki, J. et al. Insulin Resistance is Associated with Increased Cholesterol Synthesis and Decreased Cholesterol Absorption in Normoglycemic Men. Journal of Lipid Research. 2004. 45:507-512.
26. Gerhardt AL, et al. Full-Fat Rice Bran and Oat Bran Similarly Reduce Hypercholesterolemia in Humans. The Journal of Nutrition. 1998. 128: 865-869.
27. Sanders T, et al. The Influence of Rice Bran on plasma lipids and lipoproteins in Human volunteers. European Journal of Clinical Nutrition. 1992; 46: 167-172
28. Qureshi A, et al. Novel Tocotrienols of Rice Bran Suppress Cholesterogensis in Heredierary Hyper cholestemy swine. Journal of Nutrition. 2001; 131(2): 223-30.
29. Qureshi AA, et al. Isolation and Identification of Novel Tocotrienols from Rice Bran with Hypocholesterolemic, Antioxidant, Antitumor Properties. Journal of Agriculture and Food Chemistry. 2000. 48:3130-3140.
30. Xu Z, et al. Antioxidant Activity of Tocopherols, Tocotrienols, and γ Oryzanol Components from Rice Bran Against Cholesterol Oxidation Accelerated by 2,2’-azobis (2-methylpropionamidine Dihydrochloride. Journal of Agriculture and Food Chemistry. 2001. 49:2077-2081.
31. Morris BW, et al. Chromium homeostasis in patients with type II (NIDDM) diabetes. Journal of Trace Elements and Medical Biology. 1999.13:57-61.
32. Ding W, et al. Serum and urine chromium concentrations in elderly diabetics. Biological Trace Element Research. 1998. 63:231-237.
33. Ekmekcioglu C, et al. Concentrations of seven trace elements in different hematological matrices in patients with Type 2 diabetes as compared to healthy controls. Biological Trace Element Research. 2001. 79:205-219.
34. Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Archives of Internal Medicine. 1996;156:1143-1148.
35. Thornalley PJ, et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007 50(10)
36. El-Yazigi A, et al. Urinary excretion of chromium, copper, and manganese in diabetes mellitus and associated disorders. Diabetes Research. 1991. 18:129-134.
37. Lima MDL, et al. The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes. Diabetes Care. 1998. 21:682-686.
38. Paolisso G, et al. Daily Magnesium Supplements Improve Glucose Handling in Elderly Subjects. American Journal of Clinical Nutrition. 1991. 55:1161-1167.
39. Rodríquez-Morán M, et al. Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects – A Randomized Double-Blind Controlled Trial. Diabetes Care. 2003. 26:1147-1152.
40. Anderson RA, et al. Elevated Intakes of Supplemental Chromium Improve Glucose and Insulin Variables in Individuals with Type 2 Diabetes. Diabetes. 1997. 46:1786-1791.
41. Cefalu WT, et al. Effect of Chromium Picolinate on Insulin sensitivity in vivo. Journal of Trace Elements in Experimental Medicine. 1999. 12:71-83.
42. Offenbacher E, et al. Beneficial Effect of Chromium-rich Yeast on Glucose Tolerance and Blood Lipids in Elderly Subjects. Diabetes. 1980. 29:919-925.
43. Thomas V, et al. Effect of Chromium Nicotinic Acid Supplementation on Selected Cardiovascular Disease Risk Factors. Biological Trace Element Research. 1996. 55:297-305.
44. Uusitupa M, et al. Chromium Supplementation in Impaired Glucose Tolerance of Elderly: Effects on Blood Glucose, Plasma Insulin, C-Peptide and Lipid Levels. British Journal of Nutrition. 1992. 68:209-216.
45. FNB - Food and Nutrition Board, Institute of Medicine. Chromium. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001:197-223.
46. Kagan VE, et al. Recycling of vitamin E in human low density lipoproteins. Journal of Lipid Research. 1992. 33:385-397.



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